Major effect of transcytosis on nano drug delivery to pancreatic cancer

Major effect of transcytosis on nano drug delivery to pancreatic cancer

Blog Article

We demonstrated that activated transcytosis is a major mechanism to complement the classic enhanced Dog Dehydrated permeability and retention effect in pancreatic cancer.This was achieved by using an iRGD peptide that triggers transcytosis pathway at the tumor site.Co-administration of unconjugated iRGD substantially improved the effect of the chemotherapeutics delivering nanocarrier, and resulted in survival improvement in mice.

Since the iRGD effect is commensurate with Crown neuropilin-1 expression on tumor vasculature, it is necessary to contemplate a personalized approach to implement this technology.